PharmacoGenomics (PGx)
Patient-specific genomics for effective medication prescribing
Introduction
Genetics-Guided Medication Management
Pharmacogenomic (PGx) testing analyzes specific genes that influence how a person processes and responds to medications. This insight allows providers to predict whether a drug will be effective, poorly tolerated, or potentially harmful—before prescribing it. By tailoring drug selection and dosage to a patient’s genetic profile, PGx testing helps reduce adverse drug reactions and enhances therapeutic outcomes, supporting safer, more personalized treatment plans across a wide range of specialties.
Why the Test Is Significant
Optimizes Selection & Dosing
Improving treatment outcomes (“right drug, right dose, first time”).
Reduces Drug Reactions
Enhancing patient safety and lowering healthcare costs.
Provides Valuable Insights
Managing patients on multiple medications (polypharmacy).
Genomic Medication
Moves medicine towards a more personalized approach.
Unknown and Interesting Facts
Genetic variation in drug metabolism plays a significant role in treatment success or failure. For instance, differences in the CYP2D6 gene alone affect how patients process nearly 25% of all commonly prescribed medications—including opioids, antidepressants, beta-blockers, and more. A single pharmacogenomic test offers lifelong value, guiding safer, more effective prescribing decisions across multiple therapeutic areas and improving patient outcomes by minimizing trial-and-error approaches.
Medical Necessity and Signs/Symptoms
- History of adverse drug reactions or side effects
- Ineffectiveness of standard medication doses
- Initiation of PGx-relevant medications (e.g., clopidogrel, warfarin)
- Patients prescribed antidepressants, statins, or chemotherapy
- Use of multiple medications (polypharmacy)
- Personal or family history of drug sensitivity
- Planning complex medication regimens
- Medication selection for psychiatric, cardiovascular, or oncology care
Post-Test Support
Elite Clinical Laboratory provides comprehensive PGx reports that connect genetic findings to actionable prescribing recommendations—based on FDA labeling and CPIC guidelines. Our support team assists clinicians in navigating gene-drug interactions, optimizing treatment plans, and adjusting dosages to reduce adverse effects. When needed, we offer collaboration with clinical pharmacists to ensure personalized, evidence-based medication strategies that improve patient safety and therapeutic success.