CancerGenomics (CGx)
Identifying inherited mutations linked to cancer syndromes.
Introduction
Genetic Screening for Cancer Risk
The CancerGenomics (CGx) panel evaluates multiple genes associated with increased inherited risk for a variety of cancers, including breast, ovarian, colorectal (Lynch syndrome), prostate, pancreatic, melanoma, and more. By identifying genetic predispositions, this test enables proactive risk management, such as earlier screenings, lifestyle modifications, and preventive interventions. It also supports family counseling and cascade testing for at-risk relatives.
Why the Test Is Significant
Enhanced Surveillance
Identifies those needing earlier or more frequent cancer screening
Informs Preventive Care
Informs decisions on preventive surgery or chemoprevention
Guides Targeted Treatment
Helps tailor therapies like PARP inhibitors for mutation carriers
Facilitates Family Testing
Enables relatives to assess and manage inherited cancer risk
Unknown and Interesting Facts
Roughly 5–10% of all cancers result from inherited mutations in high-risk genes such as BRCA1, BRCA2, or those associated with Lynch syndrome. Carrying such a mutation doesn’t guarantee cancer will develop—but it significantly increases lifetime risk. Genetic testing helps identify individuals who can benefit from intensified surveillance, preventive measures, or early therapeutic intervention. In many cases, family members can also be tested to clarify their own risk and take proactive steps in managing their health.
Medical Necessity and Signs/Symptoms
- Early-onset cancer diagnoses (typically before age 50)
- Multiple primary cancers in the same individual
- Family clustering of related cancers across generations
- Rare cancer types (e.g., male breast cancer, ovarian cancer)
- Known familial mutations (e.g., BRCA, MLH1, etc.)
- History of colorectal, endometrial, or pancreatic cancer
- Patients eligible based on NCCN or other clinical criteria
- Individuals seeking risk-based preventive guidance
Post-Test Support
Elite Clinical Laboratory provides detailed reports with expert genetic interpretation tailored to hereditary cancer syndromes. We work closely with certified genetic counselors to support patients and families in understanding results, exploring surveillance or preventive strategies, and managing emotional and clinical implications. Referrals to oncology specialists are also facilitated, helping ensure that each patient’s care is aligned with the latest evidence-based guidelines.